Delta-8 and Delta-9 THC Research References (2024–2025)

Dec 5, 2025

hemp
TopicReference
Sleep & Brain FunctionNichols, J. M., & Kaplan, B. L. (2024). Opposite effects of delta-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology. Psychopharmacology, 241(9), 1815–1825.
Kruger, D. J., & Kruger, J. S. (2021). Consumer experiences with Delta-8-THC: Medical use, pharmaceutical substitution, and comparisons with Delta-9-THC. Journal of Cannabis Research, 3(1), 46.
WebMD. (2025). Delta-8 THC: What you need to know about this cannabinoid.
Antidepressant EffectsEl-Alfy, A. T., et al. (2010). Antidepressant-like effect of Δ9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L. Pharmacology Biochemistry and Behavior, 95(4), 434–442.
Pellicane, M. J., & Cundiff, K. R. (2024). Delta-8- and Delta-9-THC use frequency, use motives, and mental health outcomes. Journal of Psychoactive Drugs, 56(2), 199–205.
Comparative PotencyCannabis Evidence. (2024). New research from Johns Hopkins University found the hemp-derived Delta-8 THC to be less potent than Delta-9 THC.