| Cannabidiol (CBD) and cognitive function in older adults: a mini review | Frontiers in Psychiatry (2025) | CBD may support cognitive health in older adults via BDNF upregulation, anti-inflammatory effects, and anxiolytic/antidepressant properties. Future research should focus on sleep, stress, and age-specific dosing. |
| Effects of cannabidiol (CBD) treatment on age-related cognitive decline in C57 mice | Frontiers in Aging Neurosci. (2025) | CBD mitigates age-related cognitive decline in preclinical models by reducing oxidative stress and modulating mitochondrial function. |
| Acute Effects of Oral Cannabinoids on Sleep and High-Density EEG in Insomnia | Journal of Sleep Research (2025) | 10 mg THC + 200 mg CBD improved sleep architecture and next-day alertness in adults with insomnia, with changes in regional brain activity observed via high-density EEG. |
| Cannabidiol and brain function: current knowledge and future perspectives | Frontiers in Pharmacology (2023) | CBD shows potential in treating anxiety, sleep problems, and depression, with mechanisms involving serotonin modulation and neuroprotection. |
| Eight Weeks of Daily Cannabidiol Supplementation Improves Sleep Quality and Immune Cell Cytotoxicity | Nutrients (2023) | Daily 50 mg CBD improved sleep quality and natural killer cell function in healthy adults, suggesting broader mental health and immune benefits. |
| CBD lengthens sleep but shortens ripples and leads to intact simple but worse cumulative memory | PMC (2025) | CBD promotes sleep in preclinical/clinical studies, but high doses may impact memory consolidation. Potential as a novel therapeutic for sleep and neuropsychiatric disorders. |
| Cannabidiol in Anxiety and Sleep: A Large Case Series | PMC (2019, cited in 2025) | CBD reduced anxiety and improved sleep in a large clinical sample, with sustained benefits and few side effects. |
| Cannabis extract relieves chronic back pain and improves sleep (VER-01 trial) | Nature Medicine (2025) | Low-THC cannabis extract (VER-01) reduced chronic back pain and improved sleep and quality of life in a large phase 3 trial. |
